Low Dose Naltrexone (LDN)
Certification for Healthcare Providers
$149
Learn LDN prescribing with Dr. Stephen Petteruti. This online provider course covers dosing, titration, safety, compounding, monitoring, and patient selection.
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45-minutes
Time Investment
Lifetime
Access
Dr. Stephen Petteruti
Instructor
Comprehensive Guidance for Prescribing Low Dose Naltrexone
Low-dose naltrexone is an off-label therapy utilized by integrative and functional medicine providers in specific clinical contexts. Its dosing, titration, patient selection, and anticipated therapeutic response differ significantly from those associated with conventional naltrexone administration.
Common challenges in low-dose naltrexone prescribing include premature discontinuation, rapid dose escalation, unrecognized medication interactions, and insufficient patient preparation for gradual therapeutic effects. This course offers clinicians a structured framework for patient evaluation, treatment planning, follow-up management, and integration of low dose naltrexone into clinical practice.
The course, led by Dr. Stephen Petteruti, addresses low-dose naltrexone pharmacology, proposed mechanisms of action, dosing strategies, titration protocols, contraindications, compounding considerations, monitoring approaches, and effective patient communication. The curriculum also reviews current research, highlighting areas where evidence is promising, conflicting, or limited.
Add to CartSelf-paced
Learn on your own schedule
100% Online
Access the course from anywhere
Protocols and consent forms
Included with your purchase
What You Will Learn
Low Dose Naltrexone Pharmacology
Examine the distinctions between low-dose and standard-dose naltrexone. Review opioid-receptor activity, endorphin signaling, proposed neuroinflammatory and immune pathways, dose-response considerations, and the limitations of current research.
Patient Selection
Evaluate the appropriateness of LDN in patient care plans. The course reviews health history, current medications, opioid exposure, treatment goals, prior therapies, symptom patterns, and factors influencing treatment planning.
Dosing and Titration
Develop a structured approach to initiating doses, adjusting dosages, titration schedules, timing, and individualized treatment. The course addresses reasons some patients require slower titration and why increasing the dose does not always enhance therapeutic response.
Contraindications and Medication Conflicts
Review safety considerations that prescribers must address prior to initiating LDN, including opioid use, opioid dependence, acute withdrawal, hepatic considerations, planned procedures, acute pain management, pregnancy, and coordination with other healthcare providers.
Compounding and Formulation
Examine common dosage forms, immediate-release preparations, capsule and liquid formulations, filler selection, pharmacy communication, storage, and factors influencing treatment consistency and tolerability.
Monitoring and Follow-Up
Assess patient tolerance, document therapeutic response, adjust treatment, and determine the appropriateness of continued therapy. The course addresses treatment duration, follow-up intervals, symptom tracking, laboratory considerations, and indications for modifying or discontinuing therapy.
Managing Side Effects
Review patient-reported concerns, including sleep changes, vivid dreams, headaches, gastrointestinal symptoms, fatigue, and alterations in symptom patterns. The course examines how timing, formulation, and titration influence tolerability.
Patient Education and Expectations
Explain the rationale for prescribing LDN off-label, set patient expectations, and clarify variability in response timelines. The course provides a communication framework for discussing treatment goals, uncertainty, adherence, follow-up, and limitations of the evidence.
Practice Implementation
Develop an LDN prescribing workflow encompassing patient qualification, consultation structure, medication reconciliation, informed consent, pharmacy coordination, documentation, follow-up, refill management, staff education, and patient communication.
Clinical Applications of Low Dose Naltrexone
Review current research and clinical reasoning regarding LDN in the context of:
Chronic pain
Fibromyalgia
Neuropathic symptoms
Inflammatory conditions
Autoimmune disease
Fatigue-related conditions
Integrative cancer-support protocols
Functional and integrative medicine
The course differentiates clinical experience from established indications and instructs providers on discussing off-label use without overstating the available evidence.
Add to CartWhy Providers Struggle With LDN
LDN does not conform to conventional prescribing models. Patient responses to dosing vary, benefits may not be immediate, and some individuals require gradual titration.
Inconsistent dosing and unclear communication frequently result in early discontinuation. The course instructs providers to approach LDN as a monitored clinical strategy with defined processes for assessment, prescribing, follow-up, and adjustment.
IMU has helped me grow my business. Not only that, it has helped my patients and that is what matters to me the most! I have been able to help clients when they have certain conditions and autoimmune disorders. I love having the different protocols at my disposal! Thank you for having this program!
Learn From the Clinical Experience of Dr. Stephen Petteruti
Dr. Stephen Petteruti is a board-certified osteopathic physician with over 30 years of clinical experience in integrative, functional, and age-management medicine. He is the founder of Intellectual Medicine and Intellectual Medicine University.
Dr. Petteruti has integrated low-dose naltrexone into individualized clinical protocols and has trained healthcare providers in prescribing, patient education, clinical monitoring, and practice implementation. His instruction combines published research with insights gained from decades of patient care.
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Nurse practitioner
As a solo Nurse Practitioner, I truly appreciate the collaboration and support. Before taking these courses, I felt like I was just 'winging it'—but not anymore. The content, resources, and your willingness to answer questions have dramatically increased my confidence and contributed to the success of my venture. Thank you for everything!
Who Should Take This Course?
LDN Done Right is intended for licensed prescribing providers, including:
Physicians
Nurse practitioners
Physician assistants
Medical directors
Integrative medicine providers
Functional medicine providers
Pain-management providers
Clinicians working with chronic inflammatory or autoimmune conditions
Course implementation must remain within each provider’s prescribing authority, professional licensure, and applicable state regulations.
What Is Included?
Online, self-paced course access
Instruction from Dr. Stephen Petteruti
LDN pharmacology and mechanism review
Patient-selection framework
Dosing and titration principles
Contraindication and interaction review
Compounding and formulation guidance
Monitoring and follow-up strategies
Patient-education framework
Practice implementation guidance
Downloadable clinical resources
Intellectual Medicine University completion certificate
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Program Curriculum
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Module 1: LDN In Practice
4 lessons- Lesson 1: Objectives, Disclosures and Downloads
- Acknowledgment
- Lesson 2: Presentation with Dr. Petteruti
- LDN Post Test
Current Evidence and Clinical Standards
LDN use for chronic pain, fibromyalgia, autoimmune conditions, and cancer support remains off-label. Published findings vary by condition and study design. Some reviews report favorable results in selected patient populations, while other analyses find insufficient or conflicting evidence.
The course teaches providers how to evaluate this research, explain its limitations, document clinical reasoning, and monitor therapy responsibly.
Naltrexone also requires careful medication screening. The prescribing information lists opioid analgesic use, current opioid dependence, and acute opioid withdrawal among its contraindications. These safety considerations receive dedicated attention throughout the course.
Selected References
DailyMed. Naltrexone hydrochloride prescribing information and contraindications. View prescribing information
Kim PS, Fishman MA. Low-dose naltrexone for chronic pain: update and systemic review. Current Pain and Headache Reports. 2020. View on PubMed
Younger J, Noor N, McCue R, Mackey S. Low-dose naltrexone for the treatment of fibromyalgia. Arthritis & Rheumatism. 2013. View on PubMed
Yang J, Shin KM, Jung SH, et al. Safety and efficacy of low-dose naltrexone in patients with fibromyalgia: a systematic review. 2023. View on PubMed
Rassi-Mariani V, et al. The use of naltrexone in the treatment of chronic pain. 2024. View on PubMed
Vatvani AD, et al. Efficacy and safety of low-dose naltrexone for fibromyalgia: a systematic review and meta-analysis. 2024. View on PubMed
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